A última criada de Salazar (Portuguese Edition)

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De 36x26 cm. Fac-simile impressso a cores. Afonso V a quem dedicou uma poesia. Foi ao seu filho D. A recolha de homenagem deste volume diz respeito unicamente ao Distrito do Congo, em Angola. Hand written manuscript with two different calligraphies , with a beautiful front page decorated with a multi-coloured vignette containing the title partially erased in the centre, and initials.

The text, all within a red frame throughout the document, starts in the front of the second folio with a beautifully coloured decorative initial. Up to folio 10 all the paragraphs or articles start with a coloured initial. Contemporary full leather professionally repaired with raised bands and gilt tools on spine.

Our goal is to evaluate the in vivo regenerative potential of constitutively active Profilin-1 Pfn1 after lesion. Our data demonstrates that in vitro delivery of Pfn1 is a robust enhancer of axon growth with an unprecedented effect in the field. If successful, this therapy could be applicable to other conditions where axon regeneration is needed. We want also to aknowledge all the guests and participants that showed their interest and important feedback in the event. It was a real sucess! Thank you. In a new study, researchers use 3-D printing to make a porous ovary scaffold and seed it with immature egg-producing cells.

ALMOÇADEIRA - Definition and synonyms of almoçadeira in the Portuguese dictionary

They show that infertile mice implanted with the engineered ovary are able to ovulate, mate, and give birth to and nurse healthy pups in the normal way. The study is the first to achieve such a result with the help of 3-D printing, and it shows how using the technology to fine-tune the pore architecture of the scaffold is key to success. Researchers from i3S, Porto have developed a vaccine that helps to prevent bacterial infections that cause diseases such as meningitis, pneumonia, septicemia and, in the most critical cases, death from septic shock.

The bacteria that cause these pathologies Klebsiella pneumoniae, Escherichia coli, Group B Streptococcus, Streptococcus pneumoniae and Staphylococcus aureus are very resistant strains and cause "a huge problem for public health" said Pedro Madureira, a researcher at the Institute for Research and Innovation in Health i3S at the University of Porto to Lusa. Without a proper response of our immune system, bacteria "rapidly proliferate" in the bloodstream and in the infected organs, which can lead to such pathologies, considered "quite severe". The vaccine, which has already undergone laboratory tests with rats and rabbits, will move to the clinical trials phase I in the last quarter of , predicts the researcher.

According to Pedro Madureira, in addition to the vaccine, Immunethep is developing a form of therapy based on monoclonal antibodies, which neutralize the GAPDH protein, and can be used in people already infected and for whom there is no time for vaccination. Pedro Madureira also spoke about the importance and history of vaccines, in order to "demystify" some uncertainties about vaccination, and also about this being the "great achievement of immunology and medicine. Researchers from the University of Texas in the United States have developed nanovacin a vaccine given through microscopic particles against different cancers, such as skin, colon and rectum in rat models studies.

Nanovacins consist of tumor proteins that can be recognized by the immune system and are inside a synthetic polymer nanoparticle. The tiny particles are directed to the target, stimulating the immune system to trigger a response against aggressive agents such as tumors. The idea is to help the body fight cancer with its own defenses. The researchers studied a variety of tumors associated with cancers of the skin, colon, rectum, uterus, head and neck.

The study was published in the journal Nature Nanotechnology. In most cases, nanovacin slowed down tumor growth and extended animals lifespan.

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The experimental nanovacin activated the adapter protein STING, allowing the stimulation of the immune defense of the organism of the rodents against the cancer. Other vaccine production technologies have been used in immunotherapy against cancers but have higher production costs and are more complex because they involve live bacteria or multiple biological stimulants, says the University of Texas. According to the researchers, combining nanovacins with radiotherapy or other immunotherapies may in the future increase the effectiveness of cancer treatments.

Kathryn M. Edwards, the Sarah H. They have made an enormous difference in the lives of children.


  • Synonyms and antonyms of almoçadeira in the Portuguese dictionary of synonyms!
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No longer do children die of meningitis, measles, and pneumonia since the widespread use of vaccines. Just like pediatricians should stress the use of car seats when children ride in cars, they need to stress the important role of vaccines in assuring child health" says Dr. Employing motivational interviewing techniques is another way of approaching a vaccine-hesitant parent, and this involves parents verbalizing their concerns and the physician giving focused answers. Ideally, this interaction should allow the parent and patient to self-reflect and ultimately come to a place of understanding of the benefits of vaccination on their own.

With 22 active patents and six projects, i3S decided to take a step forward and launch Resolve. The first call of the program was launched on May 1, It aims to atract researchers from around the world who want to set up their research project in Oporto - seven projects, including two spin-offs, are already being supported.

The final phase of the selection process involves a jury outside the i3S, explains the person in charge. They make us a previous diagnosis of the team. This will be important to develop a roadmap in each the project and resolve teams will work in collaboration during 12 months of support. After the necessary development, Resolve supports researchers, whether they choose the licensing of start-up cration path.

In Resolve Program, the choice is made by analyzing the most appropriate way for the team and for the technology, because we believe that not all researchers need ot want to be entrepreneurs.

Synonyms and antonyms of receoso in the Portuguese dictionary of synonyms

For additional details on this news, please click here. There are also studies that associate accentuated hair loss with psychological complications, namely anxiety and depression. Proposals will be held until 27 March. The program aimed to promote health technologies with potential market interest and is open to the whole country, providing project implementation in the North of Portugal. On the first call the program received 26 applications and there are already seven teams receiving support. Selected applications include technologies for amputees, catheter coating to prevent nosocomial infection, detection of circulating tumor cells or bone implants, among others.

The goal of the RESOLVE Program is to promote knowledge transfer by providing support and management tools, including financial support for seed projects of researchers and entrepreneurs in this sector. The "Shark Tank-style" competition was held before an audience of tech industry executives at Google's New York campus in Chelsea. It has been an honor to share the stage with other amazing companies," said Didimo Cofounder Veronica Orvalho.

Didimo automatically creates 3D virtual characters from a single photo; in about 2 minutes it creates a lifelike avatar that can speak, move, and represent you in a 3D world. Platform agnostic and compatible with all 3D environments, their technology can be used in games, social media, film, AR, and VR.

Although the system has yet to undergo several tests, researchers are also working on incorporating sensors capable of measuring glucose, pH and other health related indicators of skin tissue. Portuguese researchers are participating in an international project aimed at developing a portable device to diagnose ovarian cancer in a few minutes through a drop of blood, which can act as a "simple and fast" test. The result is achieved by verifying the existence of an "innovative" biomarker, identified by this team of researchers. This portable technology developed by the team is different from the ones currently in the market and allows for greater flexibility in terms of monitoring a patient even after she has already been diagnosed with ovarian cancer.

In addition, the diagnosis achieved with this device, which was developed in partnership with the Swansea University College of Engineering and the NanoHealth Center in the United Kingdom, allows patients to have "more appropriate" therapy. Traditional examinations for its detection undergo transvaginal ultrasonography and analysis of CA biomarker levels in the blood through the Elisa test, "more expensive" than this new technology.

According to the researcher, another drawback of the traditional tests is the biomarker CA, classically used to diagnose this pathology, which is "not specific enough". In this sense, "the need of a test like this was actually very great", since it makes possible an early diagnosis, she continued. The technology, which is now in an validation phase, began about five years ago. The "AntiBioCoat" project, developed by i3S researchers, proposes a new type of antiadhesive coating for catheters, and the "Delox", from the University of Lisbon, which presented a new hydrogen peroxide vaporization process for sterilization in hospital settings.

The event will take place on the 28th of September at Corino de Andrade Auditorium at i3S with the following Program:. The U. Food and Drug Administration issued a historic action today making the first gene therapy available in the United States, ushering in a new approach to the treatment of cancer and other serious and life-threatening diseases. The FDA approved Kymriah tisagenlecleucel for certain pediatric and young adult patients with a form of acute lymphoblastic leukemia ALL.

Kymriah, a cell-based gene therapy, is approved in the United States for the treatment of patients up to 25 years of age with B-cell precursor ALL that is refractory or in second or later relapse. For additional information, please check the FDA link. Two months ago, through the ScaleUp Porto project, the City Council invited the entrepreneurial community to propose activities that reflect the vitality of the city's ecosystem, attributing new dynamics to it in terms of technology and innovation. For this purpose, it provides 70 thousand euros. From dozens of applications received, eight projects were selected, which by the end of this year will inspire the city and its entrepreneurial spirit.

The selected proposals begin to be implemented already in the current month and run until 31 December Researchers at i3S have developed a method that may help diagnose depression through blood tests. In the near future, MyRNA will create a kit that promises to contribute to a happier world. For additional information, please visit the link. ARNanoFilm technology comprises the incorporation of antiretroviral drug-loaded nanoparticles into thin polymeric films. These systems are intended to be placed in the vagina in order to prevent male-to-female sexual transmission of HIV.

It is expected that drug-loaded nanoparticles-in-films may provide enhanced safety and efficacy as compared to more conventional formulations previously tested in clinical trials. For additional information please visit the online dissemination on the following links:. The deadline for applications is the 7th of September, and the prize will be announced on the 28th of September. It thus greatly facilitates the referral process and ensures dermatologists receive relevant data for triage.

On top of that, it offers further support through its automatic melanoma risk assessment tool. The re-emergence of tuberculosis TB associated with modern epidemics and immune therapies threatens the progress made in controlling this disease. Tailor-made interventions are needed to tackle the many faces of TB, in particular the transition from latency to infectious, active disease.

Developing molecular-based point-of-care tests to stratify the estimated 2 billion latently infected individuals for their risk of reactivation would allow focusing treatment on those at higher risk, considerably reducing the number of people undergoing preventive antibiotherapy and the toxic side effects associated with it.


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    Circulating tumor cells CTCs shedding from the primary tumor have the ability to invade other organs, causing metastasis. Their study allows continuous and real-time monitoring of metastatic cancer progression based on a low invasive sampling in cancer patients, constituting the so-called liquid biopsy.

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